The Eagle Lab in Douglas is rebranding, as Barclays plans to step back.
The Lab was established by the bank along with Chamber of Commerce and the Department for Enterprise in 2018.
The collaborative space is located at Queen Victoria House on Victoria Street, and will be taken over by Physis Ltd who already operate the upper floors of the building.
Chamber has confirmed there will be no interruption to access to the facility while its rebranded as QVHclub.