Work will take place on East Quay in Peel for at least five months from next month.
It's been confirmed Manx Utilities will be laying a new water main and sewers, commencing on Monday, September 7.
The route will be closed to through-traffic although each end of the 60m working area will be accessible and the quayside will be accessible for marine operations.
Manx Utilities is sending out a letter to all Peel residents to let them know oft he closure.
A drop-in session at the Peel Centenary Centre will take place next Thursday from 5pm to 7.30pm to review the pipe-laying plans.