The police says that the Mountain Road, and roads in Onchan and Laxey are impassable.
Officers say that snow and ice sheets make the roads dangerous to use.
The Department of Infrastructure is working to improve conditions.
But it asks drivers to consider whether their drive is necessary in the mean time.
New youth club coming to the North
Bus Vannin issues zero-tolerance statement after abuse
Mountain Road closed again this morning
Four more ferry crossings affected by weather
Bottleneck car park closes in face of weather
Weather warning issued for high tides tomorrow
Two more ferry crossings called off
Plantation to close for tree felling work