Part of the Mountain Road will be closed for much of Thursday while emergency work takes place.
The Department of Infrastructure says the section is due to remain shut until around 3.30pm.
It says its contractors need to carry out work on trees near the Waterworks.
As a result, the route will be shut between Barrule Park in Ramsey and the Bungalow.
Ramsey roads shut because of coastal overtopping
MHK writes to Post Office about bill-paying restrictions
£7.7m cost by Manx Care staff sickness
30.5% hike to rates in Andreas
Only some war pensions discounted from care charges
Single car crash at Ballacraine
Minister releases number of non-toilet trained school starters
Yellow weather warning for hill snow