Manx Utilities says motorists face six months of misery as it improves the capital's sewage system.
Work on a 23-week project on the Old Castletown Road will start on Thursday.
Kewaigue's pumping station will be replaced, and work will take place on the Old Castletown Road and Heron & Brearley brewery site.
There'll be a number of road closures and traffic restrictions between Thursday, April 3 and Wednesday, April 16.
Minister can't say about specifics of bail breaches
Government income from nursing care placements rises
Tyson Fury's move to Island confirmed
Students invited to apply for paid summer placements
Heritage body's land totals thousands of acres
Key windfarm meeting delayed
13 arrested in drink-drive campaign
Laxey road shut until January