Manx Utilities says motorists face six months of misery as it improves the capital's sewage system.
Work on a 23-week project on the Old Castletown Road will start on Thursday.
Kewaigue's pumping station will be replaced, and work will take place on the Old Castletown Road and Heron & Brearley brewery site.
There'll be a number of road closures and traffic restrictions between Thursday, April 3 and Wednesday, April 16.
Manxnet email users warned about scam as service becomes paid-for
Over 100 claims for damage to government property
MHK demands U-turn on MiCards
No sailings to Liverpool this weekend due to terminal works
Passport and immigration public counters to be shut tomorrow
Police appealing to public after street fight
They say you want to Revolut shun...
Rachel Reeves to celebrate budget in IOM-owned pub, says MP